AREDS 2 vs. AREDS: What’s the Difference and Which One Should You Take?

If you're researching AREDS vs AREDS 2, you're likely looking for the best way to support your vision—especially if you're concerned about age-related macular degeneration (AMD). Both AREDS and AREDS 2 are scientifically backed formulas developed through clinical trials by the National Eye Institute, but AREDS 2 offers key upgrades. In this post, we’ll compare the two, highlight their differences, and help you choose the right eye supplement based on your needs.
? Ingredient Comparison: AREDS vs AREDS 2
The original AREDS formula was a breakthrough in slowing the progression of AMD, but later studies showed room for improvement.
Ingredient | AREDS | AREDS 2 |
---|---|---|
Vitamin C (500mg) | ✔️ | ✔️ |
Vitamin E (400 IU) | ✔️ | ✔️ |
Zinc (80mg) | ✔️ | ✔️ (Some variants reduced to 25-40mg) |
Copper (2mg) | ✔️ | ✔️ |
Beta-Carotene (15mg) | ✔️ (synthetic) | ❌ Removed due to lung cancer risk in smokers |
Lutein + Zeaxanthin | ❌ Not included | ✔️ Plant-based antioxidants, safer alternative |
Omega-3s | ❌ Not included | Optional in newer AREDS 2 blends |
✅ AREDS 2 benefits over original AREDS include removing beta-carotene and adding lutein and zeaxanthin, which are safer for smokers and more effective at protecting the retina.
? Clinical Study Outcomes: How Effective Are These Formulas?
The original AREDS study (2001) showed that high-dose antioxidants plus zinc could reduce the risk of AMD progression by up to 25% over 5 years.
The AREDS 2 study (2013) refined the formula:
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Replaced beta-carotene with lutein and zeaxanthin
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Showed similar or improved protection against AMD
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Recommended for long-term use, especially in older adults with intermediate or advanced AMD
? Choosing the Right Eye Supplement for You
Recommendations based on age and eye health status:
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Under 50 / General Eye Health: Consider standard antioxidants or Vitamin D3 for Immunity & Bone Health to support overall wellness.
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50+ with Family History or Early AMD: Choose a lutein + zeaxanthin-based formula like the Classic AREDS 2 Softgels or Classic AREDS 2 Capsules.
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Smokers or Former Smokers: Avoid beta-carotene and go for zinc-free or reduced-zinc options like Classic AREDS 2 Zinc-Free.
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Advanced Macular Support: For an added boost, try AREDS 2 Advanced Macular Support with Bilberry (180 Capsules).
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Eye & Heart Combo: If you're looking for complete macular and cardiovascular support, check out AREDS 2 + Omega-3 Macular Health Formula (270 Softgels).
? Bonus Options: AREDS 2 in Different Forms
For those who prefer powders or need custom dosing:
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Classic AREDS 2 Multi Powder – easy mixing with drinks
Explore the full lineup:
? Final Thoughts: AREDS vs AREDS 2 – Which Is Right?
When comparing AREDS vs AREDS 2, the updated version is the clear winner for most people, especially for those with concerns about safety, inflammation, and modern nutritional science. With added lutein, zeaxanthin, and options for omega-3 support, AREDS 2 offers a smart, well-rounded approach to choosing the right eye supplement.
Explore other supplements for joint and bone support:
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